Research
The Imitola Lab has maintained a focus in developing human models of neuroinflammation and education of trainees in the field of regenerative neuroimmunology. We have contributed to the generation of a new model of microglia from patient monocytes, (Sci Transl Med. 2017 Dec 20;9:421) as well as tools to analyze phenotype-genotype relationships of iPSCs models of neurological diseases (EMBO Mol Med. 2017 Dec;9(12):1742) our work aims for translational solutions with regenerative neuroimmunology principles for neurodegeneration in progressive MS and AD.
The Imitola Lab has maintained a focus in developing human models of neuroinflammation and education of trainees in the field of regenerative neuroimmunology. We have contributed to the generation of a new model of microglia from patient monocytes, (Sci Transl Med. 2017 Dec 20;9:421) as well as tools to analyze phenotype-genotype relationships of iPSCs models of neurological diseases (EMBO Mol Med. 2017 Dec;9(12):1742) our work aims for translational solutions with regenerative neuroimmunology principles for neurodegeneration in progressive MS and AD.
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Human Models of Inflammatory-Induced Neurodegeneration
There is a lack of human-based translational models for neurodegenerative diseases. In order to study genetics that underlie the phenotypic functions of human NSCs in the context of neuroinflammation, Our lab studies the effects of inflammation on human-derived in vitro induced pluripotent stem cell (iPSC) cerebral organoids. These models can help to validate potential pathways to find human-specific mechanisms and targets for repair that can be applicable to AD and MS. Semin Cell Dev Biol. 2019 Aug 16 Cell Stem Cell. 2017 Feb 2;20(2):157 Translation of stem cell research and care delivery in progressive Multiple Sclerosis patients. We investigate new methods to advance research and delivery of stem cells in patients with progressive MS. To improve personalized patient education and care for patients with the most challenging cases of MS, bridging our MS Care and Research together. In addition to tackling challenges like the phenomena of "stem cell tourism". Proc Natl Acad Sci U S A. 2019 Apr 30 JAMA Neurol. 2015 Nov;72(11):134 |
Confocal imaging of radial glia transcription factor PAX6 and the newborn neurons marker (DCX) doublecortin in Human Cerebral Organoids
Z-stack rendering of engineered 3D-network of human neurons carrying fluorescent reporters.
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Influence of Immune System on Glioma Stem Cells programs
We investigate the mechanisms of glioma stem cells (GSC) responses to an immune microenvironment using deep sequencing, gene expression analysis and functional studies in Glioblastoma Organoids. Oncogene. 2017 Jan 12;36(2):263 |
Confocal imaging of migratory progenitors in Human brain organoids
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