Our research focus in clinical and regenerative neuroimmunology:
1) Mechanisms of progression and lack of repair in MS, focusing on the impact of immunity on neural stem cells, Oligodendrocyte progenitor cells and neurons genetic programs.
2) Modeling neuroimmunological microenvironments using patient derived cells, iPSCs and cerebral organoids.
3) Clinical outcomes of the impact of social determinants and environmental exposures in molecular progression in MS.
We use an integrative approach including immunology, developmental, genetics, cell and computational biology, epidemiology and quantitative imaging in the highly collaborative environment of UConn Health, The Jackson Laboratory for Genomic Medicine and national and international collaborators.
We aim to find novel convergent pathways to improve outcomes from early MS to novel molecular targets to prevent progression and improve repair in MS.
1) Mechanisms of progression and lack of repair in MS, focusing on the impact of immunity on neural stem cells, Oligodendrocyte progenitor cells and neurons genetic programs.
2) Modeling neuroimmunological microenvironments using patient derived cells, iPSCs and cerebral organoids.
3) Clinical outcomes of the impact of social determinants and environmental exposures in molecular progression in MS.
We use an integrative approach including immunology, developmental, genetics, cell and computational biology, epidemiology and quantitative imaging in the highly collaborative environment of UConn Health, The Jackson Laboratory for Genomic Medicine and national and international collaborators.
We aim to find novel convergent pathways to improve outcomes from early MS to novel molecular targets to prevent progression and improve repair in MS.
Our affiliations
Jaime Imitola Laboratory
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Research Fellowships are available to highly motivated candidates that are interested in pursuing academic neurology careers. Please contact Professor Imitola via email imitola@uchc.edu with a copy of your CV and three references.
9/1/2023
Congratulations to Dr. Imitola for his Promotion to Full Professor of Neurology.
8/16/2023
Sharing our paper delineating a mechanism for loss of self-renewal of Neural stem cells during neuroinflammation, the findings may be relevant to progression in MS.
https://www.frontiersin.org/articles/10.3389/fncel.2023.1156802/full
5/12/2023
Congratulations to Dr. Imitola for his selection as Student Nominated Graduate Faculty Career Mentor of the Year Award for the 2022-2023 academic year.
3/6/2023
Congratulations to Tim Nolan, Katie Julie in their residency matches
Congratulations to UConn MSIV Shivam Patel for his manuscript acceptance in Journal of Neuroimmaging.
9/1/2023
Congratulations to Dr. Imitola for his Promotion to Full Professor of Neurology.
8/16/2023
Sharing our paper delineating a mechanism for loss of self-renewal of Neural stem cells during neuroinflammation, the findings may be relevant to progression in MS.
https://www.frontiersin.org/articles/10.3389/fncel.2023.1156802/full
5/12/2023
Congratulations to Dr. Imitola for his selection as Student Nominated Graduate Faculty Career Mentor of the Year Award for the 2022-2023 academic year.
3/6/2023
Congratulations to Tim Nolan, Katie Julie in their residency matches
Congratulations to UConn MSIV Shivam Patel for his manuscript acceptance in Journal of Neuroimmaging.
UCONN Healthに所属する当研究室では、免疫系と神経幹細胞との相互作用に関して、神経免疫学的、かつ遺伝子学的解析を行なっております。
この知見は、神経変性および修復の理解の基盤になります。 私たちの目標は、神経免疫学の原理（再生神経免疫学）を用いながら、神経再生メカニズムの解明を発展させることです。
当研究内容に興味をお持ちの方は遠慮なく連絡先までお問い合わせください。連絡先、およびCV（英語）の添付をemailにてお願い致します。
この知見は、神経変性および修復の理解の基盤になります。 私たちの目標は、神経免疫学の原理（再生神経免疫学）を用いながら、神経再生メカニズムの解明を発展させることです。
当研究内容に興味をお持ちの方は遠慮なく連絡先までお問い合わせください。連絡先、およびCV（英語）の添付をemailにてお願い致します。