The lab have contributed with conceptual advances in the molecular biology of NSCs and Neuroinflammation. We have worked in several areas that include 1) Understanding the impact of inflammation of NSCs during injury. 2) Understanding the loss of self-renewal on NSCs in models of MS 3) Using Stem cells and organoids to model mechanism of NSCs dysfunction and neurodegeneration 4) Developing imaging techniques to study neuroinflammation in-vivo and ex-vivo with Quantitative Multimodal imaging (QMI).
Examples of Quantitative Multimodal Imaging studies in Neuroinflammation.
PictureQuantitative Colocalization of GM-CSF receptors in Human Microglia in MS plaques. Imitola J, et al Neuroimmunol. 2018 Apr 15;317:45-54.

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First time use of Multimodal coherent anti-Stokes Raman scattering microscopy in Multiple sclerosis-like lesions in mice. Imitola J et al, J Biomed Opt 2011 Feb;16(2):021109
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Live Imaging of Immunological synapse in leptomeningeal explants in EAE mice. Kivisäkk P, Imitola J et al. Ann Neurol. 2009 Apr;65(4):457-69.
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Decreased retrograde labeling of cortical projection neurons in chronic EAE. Rasmussen S, et al Brain. 2007 Nov;130(Pt 11):2816-29
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Live imaging visualization of Microglia-T cell interaction in a model of AD. Monsonego A, Imitola J et al, Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5048-53
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4D visualization of Galectin-9 Tim-3 interaction in T cells. Zhu et al. Nat Immunol. 2005 Dec;6(12):1245-52.
Organoid Technology
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